Abstract
The change in the serum enzyme activities was studied during a 2-week hospitalization period in 93 healthy young (ages 20 to 29 years) male volunteers.1) Activities of GOT, GPT, γ-GTP and LAP were significantly elevated during the long-term hospitalization, while LDH and ALP were transiently reduced.In eight volunteers the GPT level was increased to more than the upper normal value and the γ-GTP level likewise increased in one.2) The data of subjects who gained over 1 kg during hospitalization resulted in a signifi cant elevation in GOT and a tendency toward GPT elevation.3) No clear parameter was obtained predicting a change in serum GPT activity from the data prior to the long-term hospitalization. However, the following factors related to the predictive parameters of GPT elevation might be considered:(1) Obesity before hospitalization is less than 100%.(2) GOT/GPT ratio is over 3 combined with a low GPT level before hospitalization.(3) Low level of LAP prior to hospitalization(4) No weight gain after hospitalization
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Schedule a callMore From: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
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