Порівняльний аналіз вмісту токсичних (кадмію, свинцю) та есенціальних (цинку,міді) мікроелементів у крові жінок І триместру неускладненої та ускладненої гестації

Abstract

Introduction. Modern ecological situation considering global environmental pollution by heavymetals and imbalance of trace elements create preconditions for increasing the frequency of gestationalcomplications and adverse effect on children’s health throughout all periods of growthand development, including the intrauterine stage.The aim of this study was to evaluate the content of toxic (cadmium, lead) and trace (zinc, copper)elements in women’s blood during I trimester of uncomplicated and complicated pregnancyand to assess the signifi cance of their infl uence on the gestational process.Materials and methods. Investigation of cadmium, lead, zinc and copper content in the bloodof 42 women with uncomplicated pregnancy and 50 women with gestation complicated by anemia(44.0 %) and threatened abortion (56.0 %) was carried out. Determination of metals wasevaluated by inversion voltammetry method.Results. The elevated levels of toxic elements were found in all groups of women with complicatedcourse of pregnancy. The average level of cadmium in the fi rst trimester of gestation was significantly (p 0.05), lead (r=0.12; p>0.05) and zinc (r=-0.22; p>0.05), however, it is signifi cantly(p<0.05) combined with low concentrations of copper (r=-0.31).Conclusions. The average levels of toxic metals in the blood of women with complicated gestationwere signifi cantly higher compared to the physiological course of pregnancy, while the contentof trace elements were signifi cantly lower. In the fi rst trimester of gestation, the developmentof threatened abortion was combined with high levels of lead and cadmium and low levelsof zinc and copper, and the risk of anemia was correlated with a low concentration of copper inthe blood of pregnant women.