The histone proteins of blood leukocytes under miscarriage.

Abstract

To analyze fractions of histones in lymphocytes of peripheral blood of women under physiological and complicated course of pregnancy. Three groups of female patients were examined (85 persons in all). The main group (I) included 30 women with physiological course of pregnancy; the main group (II) included women with threat of miscarriage (35 persons); control group (III) consisted of 20 healthy and without pregnancy women. The study established significant increasing of content of histone proteins under physiological development of pregnancy, especially fractions (H2A, H3, H4) and H2B as compared with control. In female patients from group II content of total histone fraction (H2A, H3, H4) remained at the level of women without pregnancy and reliably differed from similar indices of group I. The established alterations possibly are necessary for decreasing of activity of lymphocytes and development of tolerance to tissues of fetus.