Abstract
The effect of humoral immunity factors on the progress of chronic polypous rhinosinusitis remains unclear, there is no evidence of their role in the recurrence of the disease. The objective of the study was to assess the prognostic significance of humoral immunity factors (immunoglobulins) in the blood serum of patients with chronic recurrent polypous rhinosinusitis. The humoral immunity factors (immunoglobulins) were identified in 82 patients with chronic polypous rhinosinusitis (ChPRS). The share of the patients with the level of immunoglobulins M, E, sIgA above the normal range was statistically significantly higher in the patients with the recurrence of the chronic polypous process than in those without the recurrence (p < 0.001). It has been established that the risk of recurrence in the patients with IgE level above the normal range is 3.5 times higher than that in the patients with normal IgE level (RR 3.50 (1.83–6.70)), and with sIgA level exceeding the normal range it is 2.93 times higher than that in the patients with normal sIgA level (RR 2.93 (1.31–6.57)). The most significant humoral immunity factors characterizing the risk of recurrence in the patients with chronic polypous rhinosinusitis are the level of immunoglobulins E, sIgA in blood serum above the normal range in the patients who may be included in the building of a model of predicting the recurrence of chronic polypous rhinosinusitis.
Published Version
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