СОДЕРЖАНИЕ ОБЩЕГО ХОЛЕСТЕРИНА И ТРИГЛИЦЕРИДОВ В НАЗОФАРИНГЕАЛЬНОМ АСПИРАТЕ ПРИ ЦЕРЕБРАЛЬНОЙ ИШЕМИИ СРЕДНЕЙ СТЕПЕНИ ТЯЖЕСТИ У НОВОРОЖДЕННЫХ ОТ МАТЕРЕЙ С ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИЕЙ В ПЕРИОД БЕРЕМЕННОСТИ

Abstract

The contents of total cholesterol (TC) and triglycerides (TG) in nasopharyngeal aspirate were studied in 233 mature newborns from mothers with normal pregnancy and complicated with cytomegalovirus infection (CMVI). The first (control) group included 30 babies of 38-40 weeks from mothers with physiological course of pregnancy. Among the newborns with moderate cerebral ischemia and antenatal history complicated with chronic CMVI in their mothers in the second trimester of pregnancy, four groups were distinguished and each of them was divided into two subgroups. Subgroup A had patients whose mothers did not have the threat of miscarriage during pregnancy and subgroup B had children from mothers who had the threat of miscarriage in the second trimester of gestation. The second group included 50 newborns whose mothers had a latent course of chronic CMVI; the third group included 50 children from mothers with reactivation of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:200-1:400, the avidity index of IgG antibodies to CMV was more than 65%); the fourth group consisted of 51 newborns whose mothers suffered an acute form of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:200-1:800, avidity index of IgG antibodies to CMV was more than 65%); and the fifth group had 52 children from mothers who suffered a reactivation of chronic CMVI (antibody titers of IgM to CMV were 1:200-1:400, antibody titers of IgG to CMV were 1:400-1:600, avidity index of IgG antibodies to CMV was more than 65%). The children of 2A, 3A and 4A subgroups, in comparison with the first group, in nasopharyngeal aspirate did not have any significant changes in the contents of TC and TG. In 5A subgroup against the absence of reliable differences of TG concentration there was registered a fall of TC level till 0.189±0.015 mmole/L (in control and 2A subgroup it was 0.250±0.016 mmole/L, p<0.01 and 0.246±0.015 mmole/L, p<0.01, respectively). When comparing the lipid composition of nasopharyngeal aspirate in newborns of 2B and 3B subgroups with the one taken from healthy children there were not found any significant differences in TC and TG. But in 4B and 5B subgroups there was a fall of TC till 0.191±0.014 mmol/L (p<0.01) and till 0.146±0.010 mmole/L (p<0.001), while the values of TG grew till 0.169±0.009 mmole/L (p<0.05) and till 0.198±0.009 mmole/L (p<0.001); at the same time the contents of TG in the first group was only 0.142±0.008 mmole/L. Thus in newborns with moderate cerebral ischemia and antenatal history complicated with 4 times growth of antibody titers of IgG to CMV and the threat of miscarriage in the second trimester of gestation, the decrease of TC can lead to less expressed compensatory-adaptive reactions, and the increase of TG, including fatty acids peroxides, results in the starting of mechanisms of intrauterine degradation of pulmonary surfactant and membrane-destructive processes in central nervous system.