Abstract
The effectiveness of licorice preparations, essential phospholipids, and their combination has been assessed in comparative tests on white rats with experimental hepatitis. It has been established that three licorice-based drugs (glycyrrhizic acid, licorice root tincture, and liquiriton) exhibited approximately equal activity, while licorice syrup exhibited no hepatoprotective properties. The results suggest that triterpene and flavonoid glycosides give approximately equal contributions to the hepatoprotective activity of licorice root. Among the analogs of essential phospholipids, the maximum effect was observed for essentiale, which exceeded the activity of eslidin and the more so that of essliver forte. The maximum efficiency in the treatment of experimental toxic hepatitis was obtained with a combined preparation of essential phospholipids and licorice (phosphogliv), which exhibited a much more pronounced hepatoprotective activity in comparison to the effects of separate components.
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