コラーゲン・シリコーン複合体人工粘膜の口腔粘膜欠損部への臨床応用に関する検討

Abstract

In recent years, freeze-dried dura, porcine skin, chitin membrane, and other materials have been used as occlusive wound dressings for burns, donor sites, graft sites, and oral mucosal defects. However, these are only temporary materials that have several disadvantages in terms of biocompatibility, infection, antigenicity, and breakdown.A new bilayer artificial mucous membrane (TERUDERMIS®, Terumo Co.) has been developed as a permanent material that promotes the reconstruction of tissue. It consists of a bottom layer of fibrillar collagen and heat-denatured collagen with dehydrothermal cross-linking, and an upper layer of a silicone elastomer.We used TERUDERMIS® successfully in the treatment of 32 patients in whom problems with the oral mucosa, including the gingiva and tongue, had developed during surgery. The material was found to be easy to handle, adhere well and promote hemostasis, relive pain, have little antigenicity, limit infection, promote rapid epithelialization, and produce newly, synthesized connective tissue with the infiltration of cellular tufts of fibroblasts and capillaries, and with minimum contraction.The results suggest that the material is safe and effective for clinical use, and merits being referred to as an “artificial mucous membrane.”