Abstract
Data on the synthesis and antimicrobial tests of some furfurylidene-containing hexahydroindazoles with pharmacophoric fragments (furan and pyrazoline cycles, nitro-, azomethyne, and other groups) are presented. The target hexahydroindazoles were obtained with 74 - 90% yields by means of reacting non-symmetrical 2-furfurylidene-6-arylidenecyclohexanones with or without donor/acceptor substituents in the furan (CH 3 , NO 2 ) and phenyl (3-NO 2 ) cycles with some hydrazines (hydrazine hydrate, phenylhydrazine). The structure of the compounds obtained was established by IR, NMR 1 H and 13 C spectroscopy. The synthesized hexahydroindazoles and halcones have been found to have antimicrobial effect against S. aureus , E. coli , P. mirabilis , Ps. aeruginosa . 2,3-diphenyl-7-(5-nitrofurfurylidene)-3,3a,4,5,6,7-hexahydroindazole exhibits a high selectivity to S. aureus .
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