Особенности влияния бета-адреномиметика гинипрала на радикальную активность нейтрофилов в крови женщин на разных этапах репродукции

Abstract

In recent years, the idea about the physiological significance of neutrophils, including during pregnancy and childbirth, has evolved significantly. There is an opinion that in the course of pregnancy, the activity of non-specific cellular immunity increases, which, in addition to performing a protective function, forms a mode of contractile activity of the uterus that is optimal for child-bearing. In obstetric practice, in order to reduce uterine hypertonicity in the treatment of miscarriage, β-adrenergic agonists are widely used. However, many aspects of their influence on the mother and the foetus remain insufficiently studied. The aim of this paper was to study the effect of Gynipral (selective β2-adrenergic agonist) on the intensity of latex-induced respiratory burst of venous blood neutrophils in women at different stages of reproduction. Using the chemiluminescence method, we showed for the first time that Gynipral, depending on the stage of reproduction, has multidirectional effect on the latex-induced radical activity of neutrophils in the venous blood of women in vitro. At a low level of radical reaction of neutrophils to latex (in the follicular phase of the cycle, during pregnancy and, which is especially important, during childbirth), Gynipral enhances the oxidative activity of cells; at a high level of radical reaction of neutrophils (during the luteal phase of the cycle and after childbirth), Gynipral inhibits it. It can be assumed that in women, catecholamines (adrenaline) during pregnancy through β2- and/or β3-adrenergic receptors increase the ability of neutrophils to produce activated forms of oxygen, while after delivery they reduce this ability. Such changes in receptor activation may be associated with the phenomenon of switching of β-adrenergic receptor coupling from Gs protein to Gi protein, which is important for regulatory mechanisms. For citation: Polezhaeva T.V., Paturova I.G., Zaytseva O.O., Solomina O.N., Khudyakov A.N., Sergushkina M.I., Dmitrieva S.L., Tsirkin V.I. Effect of Beta-Adrenergic Agonist Gynipral on the Radical Activity of Neutrophils in the Blood of Women at Different Stages of Reproduction. Journal of Medical and Biological Research, 2021, vol. 9, no. 2, pp. 171–181. DOI: 10.37482/2687-1491-Z055