Abstract
Sixteen cases of adenoid cystic carcinoma of the salivary glands were studied immunohistochemically, using antibodies against erbB gene family products that were receptor type tyrosine kinase. In addition, the relationship between the expression of c-erbB gene family products in tumor tissue, and clinicopath Ological factors was also investigated.c-erb B-2 and c-erb B-3 gene products were present in all adenoid cystic carcinomas, and their overexpression was demonstrated particularly in tubular and cribriform type.From these results, the presence of c-erb B-2 and c-erb B-3 gene products was suggested to bear some relation to carcinogenesis and tumor differentiation in adenoid cystic carcinoma.
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