ОКРЕМІ ПАРАКЛІНІЧНІ ПОКАЗНИКИ У НОВОНАРОДЖЕНИХ ХВОРИХ НА СЕПСИС, БАТЬКИ ЯКИХ ПОСТІЙНО ПРОЖИВАЛИ ЗА УМОВ РІЗНОЇ ЕКОЛОГІЧНОЇ ОБСТАНОВКИ

Abstract

Xenobiotics can have various effects on the human body, and especially on the course of fetal development. Numerous researchers point out that the nature of the external environment can negatively affect the course of certain diseases in both children and adults. Neonatal sepsis is one of the most serious diseases in neonatological practice and in our opinion is a completely unexplained topic of the impact of adverse environmental factors on the characteristics of sepsis in newborns, depending on the environmental situation of their parents. The aim of the study was to investigate the features of individual indicators of a pair of clinical trials in children with neonatal sepsis, whose parents lived permanently in different environmental conditions. Material and methods. To study this goal, a comprehensive survey of 260 newborns who in 2015-2018 suffered from neonatal sepsis. The proposed environmental risk factor (ERF) was a group-forming feature of a comprehensive assessment of the long-term load on the body of parents of newborns of anthropogenic pollution of air, water and soil in the regions, taking into account the environmental situation in regional centers. Thus, the first clinical group (main) included patients with neonatal sepsis, whose parents lived permanently in months with ERF 2.0 and more and with unfavorable environmental characteristics of the regional center. The second group (comparison) was formed by newborns with sepsis, whose parents lived permanently in areas with a low risk of adverse effects of these environmental factors on their body (ERF<2.0). Results and discussion. The content in the serum of patients with neonatal sepsis interleukins-6, -8.-10, Creactive protein, presepsin and procalcitonin reflected the activity of the systemic inflammatory response of the body to the infectious agent. It should be noted that patients of clinical group I were more likely to have a high serum content of interleukin-10, which has an anti-inflammatory effect. Thus, the content of this interleukin .35.0 pg / ml in the blood occurred in the newborn of the main group in 23.7 % of cases, and in children of the comparison group – in 18.1 % of cases. Along with a clearer definition of patients with group I high levels of anti-inflammatory interleukin-10, in newborns found a significant decrease in serum concentrations of immunoglobulins of classes A, G, M. Conclusions. The decrease in the level of these serum immunoglobulins is probably due to the immunosuppressive effect of xenobiotics on the fetus, whose mother was in the conditions of long-term action of xenobiotics. This, in turn, reduces the body's resistance of the newborn to infection and contributes to a more severe course of the infectious process. Probably, more severe manifestations of neonatal sepsis in neonates of the I clinical group are partly due to a combination of decreased immunoglobulin synthesis and increased production of interleukin-10.