ВПЛИВ МІСЦЕВОЇ ТА ЗАГАЛЬНОЇ МЕТАБОЛІЧНОЇ ТЕРАПІЇ НА СТАН ЗОРОВОГО АНАЛІЗАТОРА В ДІТЕЙ ІЗ НАБУТОЮ МІОПІЄЮ, АСОЦІЙОВАНОЮ З СИНДРОМОМ НЕДИФЕРЕНЦІЙОВАНОЇ ДИСПЛАЗІЇ СПОЛУЧНОЇ ТКАНИНИ

Abstract

Significant role in the formation of myopic refraction in children plays the syndrome of undifferentiated connective tissue dysplasia (SUCTD). On the background of metabolic abnormalities of the connective tissue occur morphological changes in the connective tissue of the sclera, which change its supporting function and contribute to the development and progression of myopia. This substantiates the expediency of the appointment of local and general metabolic therapy in the treatment of this category of children.The aim of the study – to evaluate the effect of local metabolic therapy on the state of the visual analyzer in children with acquired myopia associated with SU CTD.Materials and Methods. Оphthalmologic examination was performed on 65 children (130 eyes) from 7 to 12 years old with acquired myopia and phenotypic features of SU CTD . I group – 35 patients (70 eyes) received complex metabolic therapy for 2 months with the preparation "Cardonat", "Magnesium V6", and also eye drops "Tioretin A". The second group of observation included 15 children (30 eyes) with acquired myopia and SUDST who did not receive general and local therapy.Results and Discussion. After treatment in children of the group I, visual acuity is increased by an average of 0.15 c.u., obtained in 82.8 % of patients (58 eyes), reserves of absolute accommodation, reserve of relative accommodation by an average of 1.5 dpi and 2.5 dpi (p<0.05). In group II, on the contrary, the reduction of uncompressed visual acuity was determined at 0.09 c.u. (p<0.05), the indicators of accommodation function did not change significantly, remaining low. In the group I, only 17.1 % of patients (12 eyes) experienced an increase in clinical refraction by an average of 0.25–0.5 dpi, (p>0.05). In the group II, this indicator increased by an average of 0.42 dpi (p<0.05). The increase in the axial length of the eye was an average of 0.12 mm in the group I; 0.22 mm in the group II (p<0.05).Conclusions. Metabolic therapy by using Cardonate, Magnesium V6 and eye drops "Thioretin A" in children with myopia associated with SU CTD increases the visual acuity without correction on average by 1.8 times, increases the absolute accommodation and reserves of relative accommodation on average 2.1 and 1.9 times respectively.