Abstract
Aim of the research – to make a comprehensive assessment of anatomical, optical, biomechanical and morphometric parameters of the eye in children with acquired myopia and syndrome of undifferentiated connective tissue dysplasia. Materials and methods. We examined patients of 2 groups: the I group – 44 children (88 eyes) with myopia of mild degree and phenotypic manifestations of connective tissue dysplasia, the II group – 40 patients (80 eyes) with myopia and without signs of connective tissue dysplasia. We measured the following parameters: corneal refractive power, corneal diameter and radius, thickness of the cornea, anterior chamber depth, lens thickness, sagittal length of the vitreous body, axial length of the eye, corneal hysteresis, peripapillary retinal nerve fiber layer thickness. Results. We revealed significant differences in the anatomical, optical and biomechanical parameters of the visual analyzer in children with myopia of mild degree on the background of the UCTD, in contrast to children with myopia and without connective tissue dysplasia, which consisted in corneal refractive power reduction to an average of 41.25 [40.62; 41.75] D, increase in the corneal radius to an average of 8.13 [7.97; 8.28] mm, the corneal diameter to an average of 12.5 [12.1; 12.7] mm, the anterior chamber depth to an average of 3.8 [3.4; 4.0] mm, the sagittal length of the vitreous body to an average of 17.6 [17.3; 18.0] mm, the axial length of eye to an average of 24.9 [24.4; 25.4] mm, decrease in corneal hysteresis to an average of 11.2 [10.6; 11.7] mm Hg. Peripapillary retinal nerve fiber layer thickness was reduced to an average of 87 [85; 93] μm. Conclusions. The obtained data can be useful in a comprehensive assessment of ophthalmic manifestations of undifferentiated connective tissue dysplasia syndrome, in myopic process development prediction and in individual treatment tactics determination.
Highlights
Aim of the research – to make a comprehensive assessment of anatomical, optical, biomechanical and morphometric parameters of the eye in children with acquired myopia and syndrome of undifferentiated connective tissue dysplasia
We examined patients of 2 groups: the I group – 44 children (88 eyes) with myopia of mild degree and phenotypic manifestations of connective tissue dysplasia, the II group – 40 patients (80 eyes) with myopia and without signs of connective tissue dysplasia
The obtained data can be useful in a comprehensive assessment of ophthalmic manifestations of undifferentiated connective tissue dysplasia syndrome, in myopic process development prediction and in individual treatment tactics determination
Summary
We examined 84 children (168 eyes) with acquired myopia of mild degree Phenotypic signs of connective tissue dysplasia were revealed in 44 patients (88 eyes) These patients made up the І observation group. The II group consisted of 40 patients (80 eyes) with myopia and without phenotypic manifestations of the UCTD. The average age of patients in the groups did not differ significantly: 9.7 ± 0.18 and 10.1 ± 0.21 (P > 0.05), respectively. The average values of myopic refraction were: -1.75 ± 0.8 dpt in patients of the I group and -1.65 ± 0.7 dpt in patients of the II group (P > 0.05). Visual acuity with correction in all patients was 1.0. Statistical processing of the obtained results we carried out on a personal computer by the program Statistica 6.0 (StatSoft Inc., License No AXXR712D833214FAN5). The result was considered to be statistically significant at P value 0.05
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