ЗНАЧЕНИЕ НЕБЛАГОПРИЯТНЫХ ФАКТОРОВ ПОСТНАТАЛЬНОГО ОНТОГЕНЕЗА В РАЗВИТИИ УГРОЗЫ НЕВЫНАШИВАНИЯ ВО ВТОРОМ ТРИМЕСТРЕ БЕРЕМЕННОСТИ У ЖЕНЩИН, ИНФИЦИРОВАННЫХ ВИРУСОМ ПРОСТОГО ГЕРПЕСА

Abstract

The features of postnatal development in 160 women with physiologic course of pregnancy and with chronic placental insufficiency in the second trimester of pregnancy in the patients infected with the herpes simplex virus type 1 (HSV-1) were studied. The first group (the control group) included 30 women with physiologic course of pregnancy. The second group had 41 patients with chronic placental insufficiency of herpes etiology. The third group consisted of 89 women with chronic placental insufficiency and the threat of premature delivery caused by HSV-1. It was found out that in neonatal period of development and in the course of the first year of life the patients of the third group unlike the women of the second group oftener had bottle feeding (30.3 and 9.8%, respectively, р<0.05) and the period of breast feeding of less than 6 months (39.3 and 14.6%, respectively, р<0.05), and in the early childhood and infancy there was the combination of chicken pox and Botkin’s disease (39.3 and 7.3%, respectively, p<0.05), as well as enteritis and enterocolitis (28.1 and 7.3%, respectively, р<0.05). The women in the third group unlike the patients of the second group in the early childhood oftener had acute respiratory virus infections (40.4 and 14.6%, respectively, р<0.05) and lymphadenopathy (37.1 and 12.2%, respectively, р<0.05), and in the school and middle age there was algodismenorrhea (34.8 and 12.2%, respectively, р<0.05), cervical erosion (56.2 and 24,4%, respectively, р<0.05), a big number of gynecological operations (21.3 and 4.9%, respectively, р<0.05) and chronic rhinitis (47.2 and 19.5%, respectively, р<0.05). In the third group unlike the second one the signs of the secondary immunodeficiency prevailed. They were revealed through early infecting with VSH-1 (26.9 and 7.3%, respectively, р<0.05%), reactivation (identification of IgM to HSV-1) of chronic herpesvirus infection (21.3 and 4.9%, respectively, р<0.05%), thrush (16.9 and 2.4%, respectively, р<0.05) and relapsing course of Herpes labialis (22.5 and 4.9%, respectively, p<0.05). We suggest an important role of immunodeficiency in pathogenesis of the threat of premature delivery of herpes virus genesis in the second trimester of gestation and the necessity of the use of immunomodulatory medications for its treatment.