Abstract

A new automated method for the quantitative determination of an ascorbic acid in substance, injection forms and tablets has been developed and validated. The proposed method is based on the capillary electrophoresis in two variants: (i) capillary zone electrophoresis and (ii) micellar electrokinetic chromatography. The method shows high reproducibility, repeatability, and good precision (with both within-run and between-run coefficients of variation lower than 1%). The method measures ascorbic acid in a proportional and linear manner (r = 0.999) with a limit of detection at 8.8 mg/l. The method of capillary electrophoresis can be applied to quantitative determination of ascorbic acid in various medicinal forms. The quantity of ascorbic acid in injections amounted to 49.99 ± 0.24 mg/ml and that in tablets was 49.39 ± 0.15 mg.

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