Abstract
Half of the active members of the Japan Society of Equilibrium Research actually use steroids in the treatment of Meniere's disease (Yazawa). Nevertheless, there are only a few reports describing steroid therapy of Meniere's disease. The first aim of this study is the demonstration of the effectiveness of a steroid, prednisolone, in the treatment of Meniere's disease.In 16 patients (15 with Meniere's disease, one with delayed endolymphatic hydrops), the oral administration of prednisolone (average 15mg/day) caused significant (p<0.01) reduction of low-tone hearing loss, nystagmus, vertigo, dizziness and tinnitus.The second aim of this study is the search for and confirmation of an effective alternative to steroids to avoid their side effects and dependency. A new anti-allergic agent, Romet®, which predominantly depresses the release of histamine, was given in a dose of 3 tablets/day immediately after steroid therapy to the same patients and resulted in significant (p<0.01) improvement of hearing with reduction of dizziness and tinnitus. In a single dose given to 16 patients it caused significant (p<0.01) reduction of the same symptoms.The importance of an alternative to steroids in the treatment of Meniere's disease is emphasized, and the contribution of autoimmunity in the etiology of Meniere's disease is discussed.
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