Abstract
The authors investigated anti-allergic and anti-inflammatory mechanisms in iodine enriched eggs. Both total and neutral lipid fractionation in iodine enriched eggs suppressed the histamine release in response to an antigen challenge of passively immunized lung mast cells in a dose dependent manner. LT-C4 production in antigen challenged atopic leukocytes was also suppressed by both total and neutral lipid fractionation. The suppressive mechanisms of iodine enriched eggs were investigated using leukocyte lysate as enzyme preparations of 5-lipoxygenase system. Neutral lipid fractionation did not inhibit LT-B4 production, ie., 5-lipoxygenase activity, but did inhibit LT C4 production, i.e., LT-C4 synthase activity. Polar lipid fractionation inhibited neither LTB4 production nor LT-C4. These results suggested that neutral lipid fractionation of iodine enriched eggs modulated histamine release in lung mast cells and LT-C4 production in leukocytes with antigen provocation. Furthermore, it was possible for neutral lipid fractionation to inhibit LT C4 synthase activity in leukocytes.
Published Version
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