Abstract
Effects of cadmium (Cd) intake together with delivery-lactation to maternal renal function and bone metabolism were investigated. Increased urinary excretion of β2-MG, amino acid, and glucose was found in each groups of 2mgCd/kg and 5mgCd/kg by delivery-lactation. Moreover, bone mineral density and bone intensity of femur were decreased significantly by lactation and Cd intake, too. Moreover, bone mineral density and bone intensity of femur were also decreased significantly by lactation and Cd intake. However, these significant effect was not found in the group of 1mgCd/kg (3.5ug/kg/day intake, corresponding to Cd intake level of human). In addition, the remarkable increased osteoid volume of femur of 1mgCd/kg group was not found by Cd intake and lactation load. On the other hand, the osteoid volume of 2mgCd/kg and 5mgCd/kg were increased by Cd intake together with lactation load. The significant increase of metallothionein (MT) was not found in uterus tissue for Cd transfer of materal-to-fetrus. But the participation of MT for the inhibition of Cd transfer into fetus was suggested. Gene expression of iso-MT (I, II, III) in uterus tissue was found. But the significant increase of protein level of iso-MT-III was not found correspondingly to gene expression. From the distribution in kidney and liver of Cd on newborn infant of first day old after delivery, it was suggested that Cd of the chemical form of non-Cd-MT leaked into fetus through blood-placenta barrier and accumulated in liver.
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