Abstract
Chokeberry contains a wide range of biologically active substances with potential geroprotective activity. An ethanolic extract of chokeberry ×Sorbaronia mitschurinii (ABE) has previously been found to have a positive effect on the lifespan of Drosophila melanogaster individuals in short-term exposure (two weeks). The present study evaluated the effects of ABE on the integrity of the D. melanogaster intestinal barrier. This indicator is a marker of aging in many model organisms (nematodes, fish, and flies) and its appearance correlates with the risk of age-dependent death. Brilliant Blue FCF, a synthetic blue food coloring, was used as an indicator of intestinal barrier permeability. It was found that ABE applied before the age of 2 weeks did not significantly affect the integrity of the intestinal barrier in D. melanogaster males and females. However, treatment with ABE at the age of 4-5 weeks resulted in a 3-fold reduction (p < 0.05) in females with compromised intestinal barrier integrity at 8 weeks of age compared to untreated females of the same age. Thus, the use of chokeberry fruit extract in middle age leads to a delay in the onset of age-dependent defects of the integrity of the D. melanogaster intestinal barrier.
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