Розмариновая кислота из Salvia stepposa и ее антирадикальная активность

Abstract

Plants of the genus Sage (Salvia L., family Lamiaceae) include 700 species, which are widely used in folk medicine in many countries as medicinal raw materials. Currently, only medicinal sage (Salvia officinalis L.) is included in the State Pharmacopoeia of the Republic of Kazakhstan, but this species does not grow in the natural conditions of Central Kazakhstan. As a replacement plant, we have proposed steppe sage (Salvia stepposa Des.-Shost.), which is widespread in the Republic of Kazakhstan, has significant raw material resources and has relatively pronounced antimicrobial, anti-inflammatory, antioxidant properties due to the major component in its composition, the phenylpropanoid rosmarinic acid. Extraction of raw materials was carried out for the first time using various methods using ultrasonic cavitation, microwave extraction and maceration using water-ethanol solutions. The HPLC method was used to determine the content of rosmarinic acid in dry extracts of steppe sage. The maximum yield of extracts was observed during microwave extraction with 40% ethyl alcohol. For the subsequent standardization of medicines based on steppe sage, we isolated and identified the main component – rosmarinic acid, which has antiradical activity.