Роль бактерий рода Desulfovibrio sp. в патологии человека

Abstract

Bacteria of the genus Desulfovibrio sp. They are widespread in the environment – they are found in soil, wastewater, bottom sediments. The effect of these microorganisms on the development of pathological conditions in humans has not been fully established. Bacteria of the genus Desulfovibrio sp., gram-negative, curved microorganisms,non-spore – forming, slow-growing, anaerobic. Objective. Identification of pathogenetic features of the effect of sulfate-reducing bacteria of the genus Desulfovibrio sp. on the human. Patients and methods.167 patients who signed a voluntary informed consent was conducted among patients who applied to the Federal State Budgetary Institution "Central Research Institute of Epidemiology" for an examination of intestinal microbiocenosis. Microbiological examination of the biomaterial was carried out using traditional microbiological methods. The following blood parameters were used to assess iron metabolism in the body: hemoglobin, serum iron, ferritin, transferrin, unsaturated iron binding capacity of serum and the percentage of transferrin saturation with iron. Statistical data analysis was performed using standard descriptive statistics methods using Excel (Microsoft Corporation, 2019, USA). The statistical significance of the differences in the compared indicators was assessed using the Student's t-test the significance level of p < 0.05 (t > 2). Results. Bacteria of the genus Desulfovibrio sp. were found in 66 patients (39.5%). In the group of patients whose examination revealed bacteria of the genus Desulfovibrio sp., the number of people with anemia was 16, without anemia was 50. Among patients with the absence of bacteria of the genus Desulfovibrio sp. in the microbiocenosis. laboratory-confirmed iron metabolism disorder with the development of anemia was detected in 11 people, the absence of anemia in 90. The calculation of the odds ratio showed that the risk of anemia increases 2.6 times [95% CI 1.13–6.08] in the presence of bacteria of the genus Desulfovibrio sp in the intestine. Conclusion. It can be assumed that bacteria of the genus Desulfovibrio sp. is one of the etiological factor of the development of iron deficiency anemia in humans. Key words: microbiocenosis, iron deficiency anemia, Desulfovibrio desulfuricans