Abstract
The data of modern basic and clinical studies demonstrate that commonly used rates of the recommended daily intake of vitamin D for children (400–500 IU/day) are significantly underestimated. The article presents the results of survey and clinical studies (n =21), in which the positive dynamics of 25(OH)D concentration in the blood plasma during intake of vitamin D is noted in children and adolescents aged from 0 to 18 years. The duration of vitamin D intake in the analysed studies was from 1 to 12 months, the dose — from 800 to 4000 IU/day. According to the results of the age-specific analysis, the staircase scheme of vitamin D prescription is offered: for children aged under 4 months the daily intake of 500 IU/day of the vitamin is recommended during a year (for premature — 800-1000 IU/day), aged from 4 months to 4 years — 1000 IU/day, 4–10 years — 1500 IU/day, 10–16 years — 2000 IU/day . Therewith, this achieves the effective compensation of vitamin D deficiency (25(OH)D concentration >20 ng/ml), and also, according to some reports, the reduction of risks of infectious and allergic diseases. Safety of the recommended vitamin D intake mode is shown.
Highlights
Данные современных фундаментальных и клинических исследований демонстрируют, что повсеместно используемые нормы рекомендованного суточного потребления витамина D для детей (400–500 МЕ/сут) существенно занижены
The data of modern basic and clinical studies demonstrate that commonly used rates of the recommended daily intake of vitamin D for children (400–500 IU/day) are significantly underestimated
The article presents the results of survey and clinical studies (n = 21), in which the positive dynamics of 25(OH)D concentration in the blood plasma during intake of vitamin D is noted in children and adolescents aged from 0 to 18 years
Summary
Данные современных фундаментальных и клинических исследований демонстрируют, что повсеместно используемые нормы рекомендованного суточного потребления витамина D для детей (400–500 МЕ/сут) существенно занижены. В статье представлены результаты обзорных и клинических исследований (n = 21), в которых зафиксирована положительная динамика концентрации 25(OH)D в плазме крови на фоне применения витамина D у детей и подростков в возрасте от 0 до 18 лет. ВВЕДЕНИЕ В настоящее время повсеместно используемые нормы рекомендованного суточного потребления витамина D для детей составляют 400–500 МЕ/сут и только в осенне-зимний период [1, 2]. Вместе с тем данные современных фундаментальных и клинических исследований свидетельствуют о том, что эти дозы витамина D недостаточны для компенсации его дефицита в организме ребенка и профилактики связанной с ним коморбидной патологии [2,3,4,5].
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