Abstract
Introduction The prevalence and impact of allergic diseases continues to grow, yet the etiology remains unclear. Adverse childhood experiences (ACEs) have shown to influence the risk of various chronic diseases, but little research has been done on the risk of allergic diseases, and only on asthma. Objective To conduct a prospective study that assess the relationship between ACE and risk of various allergic diseases. Aims To examine the association between ACE and risk of allergic diseases in the context of: (1) relevant ACE and allergic disorder grouping; (2) temporal association; (3) dose-response relationship. Methods A prospective population-based study linking Danish register data on 1.1 mio parent-child pairs. With objectives, measures of ACE and allergic diseases survival analyses with relevant covariates adjusting will be used to estimate relative risk of allergic diseases when exposed to ACE. Results This study will provide results on the relative risk of allergic diseases when exposed to ACE compared to those without, while also describing the temporal and dose-reponse of the relationship. Conclusion This preliminary study will help to further advance our understanding on ACE influence on physical health, specifically in regards to immune-related disorders. As such, this study may help to build a framework for future prevention and treatment initiatives of allergic disorders.
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