ПОЛИМОРФИЗМЫ ГЕНОВ ИНТЕРЛЕЙКИНА-6, СОСУДИСТОГО ЭНДОТЕЛИАЛЬНОГО ФАКТОРА РОСТА А, CD14, С-РЕАКТИВНОГО БЕЛКА, β-ПОЛИПЕПТИДНОЙ ЦЕПИ ФИБРИНОГЕНА, АССОЦИИРОВАННЫЕ С РАЗВИТИЕМ БОЛЕЗНИ КАВАСАКИ И АНЕВРИЗМ КОРОНАРНЫХ АРТЕРИЙ, У ДЕТЕЙ ГОРОДА МОСКВЫ И МОСКОВСКОЙ ОБЛАСТИ

Abstract

Kawasaki disease (KD) is a multifactorial disease with a genetic predisposition, systemic vasculitis complicated by the formation of coronary artery aneurysms (CAA). Its pathogenesis is based on immune inflammation with an increase in the concentration of pro-inflammatory cytokines, the level of C-reactive protein (CRP), and coagulation disorder. Objective of the study: to search for polymorphisms of genes interleukin-6 (IL6), vascular endothelial growth factor A (VEGFA), cluster of differentiation CD14, CRP, fibrinogen beta chain (FGB), associated with the KD development and a predisposition to the CAA formation among patients with KD living in Moscow and the Moscow region. Materials and methods: genotyping for gene polymorphisms IL6 –174G>C (rs1800795), VEGFA –634 C>G (rs2010963), CD14 –159 C>T (rs2569190), CRP 3872 C>T (rs1205), FGB – 455 G>A (rs1800790) by PCR in 31 children 1 month – 10 years old (median age 19 months [9,0; 38,5]) with KD, among them, in 10 patients the disease was complicated by CAA formation according to echocardiography, and 30 children of the control group. Results: statistically significant differences (p<0,05) were revealed in the distribution of genotypes for polymorphisms of the CD14 –159 C>T, CRP 3872 C>T and FGB –455 G>A genes among patients with KD and children of the control group; when comparing the results of KD patients with CAA and the control group, statistically significant differences (p<0,05) were revealed only in the polymorphism CD14 –159 C>T. Conclusion: it can be assumed that these polymorphisms are associated with the development of KD and CAA in these patients.