국내 자생 엉겅퀴 6품종의 실리마린 함량 및 간 보호 효과

Abstract

Six kinds of domestically cultivated thistles were collected and studied to compare their silymarin contents, antioxidant activity alcohol detoxification and liver protection effects using rat primary hepatocyte. There are <italic>Cirsium pendulum, Cirsium setidens, Carduus crispus, Cirsium japonicum, Cirsium japonicum nakaisanum</italic>, and <italic>Cirsium japonicum spinosissimum</italic>. Six types of thistles leaves were extracted using 80% ethanol and among samples, <italic>Cirsium pendulum</italic> thistle showed highest silymarin content (61.2 mg/g DW), alcohol detoxification (15.2 mU/mL) and antioxidant activity (ABTS and DPPH radical scavenging effects). Also, <italic>Cirsium pendulum</italic> extract showed a 85% liver protection function over ethanol or hydrogen peroxide treated rat primary hepatocytes, similar effect with silymarin (87%) as positive control. In conclusion, those results indicated that <italic>Cirsium pendulum</italic> extract is likely a superior functional food ingredient with liver protection and alcohol detoxification.