СПОСОБ ВЕРИФИКАЦИИ ПЕРВИЧНОГО ГИПЕРПАРАТИРЕОЗА

Abstract

A method is proposed for the integral biochemical diagnostic of primary hyperparathyroidism to obtain reliable information about the functional state of the parathyroid glands, which allows one to assess changes in phosphorus-calcium metabolism, to predict the presence or absence of primary hyperparathyroidism, and also to control the pathological process and the effectiveness of the treatment. To determine a single integral indicator - the index of primary hyperparathyroidism (IPHPT), the ratio of calcium and phosphorus to parathyroid hormone was determined. Measurements were performed in volunteers who don’t suffer from any endocrine pathology (19 patients) and in the group of patients with primary hyperparathyroidism before and after surgical treatment (19 patients). As a result of the study, it was found that the value of IPHPT ≤ 2.46 reliably indicates the presence of primary hyperparathyroidism, and the value of IHPT > 2.46 is a measure for the absence of the parathyroid glands pathology. Thus, the proposed method for the integral biochemical diagnosis of primary hyperparathyroidism could be a reliable quantification technique of the parathyroid glands function, allowing the assessing changes in phosphorus-calcium metabolism, to predict the presence or absence of primary hyperparathyroidism, and also to be used as an objective measure for the effectiveness of the treatment.