دراسة مناعية وجزيئية لـ TLR2 في مرضى أورام الثدي

Abstract

A tumor is a mass of abnormal tissue. There are two types of breast cancer tumors: those that are non-cancerous, or ‘benign’, and those that are cancerous, which are ‘malignant’ Seventy (70) biopsy of breast tumors patients women without chemotherapy for DNA extraction for genetic polymorphism of TLR2 and local immunity study for TLR2 , fifty (50) blood sample from healthy women as control group. One hundred (100) blood sample from women with breast tumor for polymorphism of TLR2 and evaluated immune markers (TLR2).The age of women in this study ranging from (14-66) years in AL-Hilla-Teaching hospital , Imam Sadiq Hospital and Marjan hospital a period from September 2021 to October 2022.the result appearedthat By Enzyme Linked Immunosorbent Assay technique showed that the concentration of TLR2 in serum patients were (9.953±4.606) significantly increased compare with control (6.774±3.855 )respectively, The concentrations of TLR2 in serum patients were (5.599±3.550) significantly different compare with concentrations tissue (21.000 ±14.356 )respectively , For TLR2 196 to 174 del genotyping the result was significantly only deletion in (G, C , T ) between patients with chemotherapy and control ) at (p =0.003* , 0.0007* , 0.04*) respectively , also the result significantly for insertion of (G) between patients with chemotherapy and control ) at (p =0.01* )