Development of a Spectrophotometric Technique for The Estimation of Sulfamethoxazole (SMX) in its Pure also in Pharmaceutical Formulatio, using organic reagent (A1)

Abstract

A sensitive, simple, as well as accurate spectrophotometric technique to the estimation of Sulfamethoxazole (SMX) drug in pure also pharmaceutical formulations was developed. It was created by the reaction of (SMX) and organic reagent (A1) after oxidation by iron chloride and potassium periodate in acidic medium. The absorption of the product of SMX and A1 was measured at 423 nm. Linearity ranged between (0.5-22.5 μg. mL-1), molar absorptivity was (6.839 *10+3L / mol.cm), limits of detection and quantification were (0.204, 0.612 μg/ml ), respectively, the method was applied successfully to the estimation of SMX in pure and pharmaceutical formulations.