Abstract
Osteoarthritis (OA) is the most common chronic progressive joint disease. Over the last years, it has been evidenced that OA is associated with an increased risk of death, which may be explained by low-intensity chronic inflammation underlying its pathogenesis, long-term pain syndrome, and high comorbidity. Considering the above, the FDA classified OA as a serious disease that requires more careful monitoring of patients and the earliest possible prescription of effective therapy in August 2018 [1].
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