Abstract
Oil-in-water(o/w) nanoemulsions were prepared in the system of water/Span 80-Tween 80/long-chain paraffin oil via PIC method. With the increase of preparation temperature from 30 oC to 80 oC, the diameter of emulsion droplets decreased from 150 nm to 40 nm. By varying the HLB of mixed surfactants, we found that there was an optimum HLB around 13.0~14.0 corresponding to the minimum droplet size. The size of emulsion droplets increased upon increasing the ratio of oil/emulsifying agent. At , the size of nanoemulsions could be kept constant more than 2 months. The increase in preparation temperature makes it possible for producing monodisperse nanoemulsions. Once the nanoemulsion is produced, the stability against Ostwald ripening is outstanding due to the extremely low solubility of the liquid paraffin oil in the continuous phase.
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