РЕПРОДУКТИВНА ФУНКЦІЯ САМОК ЩУРІВ F1 І ПОСТНАТАЛЬНИЙ РОЗВИТОК ЩУРЕНЯТ F2 ЗА ДІЇ РІЗНИХ ДОЗ НАНОГЕРМАНІЮ ЦИТРАТУ

Abstract

The article presents the results of give to drink of female rats the water contained different levels of «nanogermanium» citrate (NGeC) on the reproductive ability of females F1 and postnatal development and viability of offspring. Studies performed on laboratory rats female divided into 4 groups: 1 – control, 2 – 10 µ, 3 – 20 µ, 4– 200 µ of Ge per kg of body weight. Rat females received the NGeC starting with suckling (together with F0 mothers) to fertilization and during pregnancy and lactation. Fertility, average litter weight, offspring sex ratio, viability, and development of sensitive and motor reflexes have been investigated. In the female of 4 group higher level of fertility (100% against 85% in control) was observed. It has been shown also higher levels of multiple pregnancy, (6.4 – 17%), average litter weight (3.1 – 15.1%) in all experimental groups and average infant rat weight (1.6 – 3.0%) — in 2–nd experimental group, on 9.8 – 11.5% — in 3–st experimental group, on 2.8 – 4% — 4–th experimental group. The animals of 2 and 3 – experimental groups are characterized by higher rate of growth up to 7 days of life. The growth intensity was higher also in the rats of 2–nd group up to 14 days of life and in 2–nd and 4–th groups — up to 27 days of life. The increasing of a number of male births – in 2 infant 4 experimental groups accelerated development and manifestation of infant sensory reactions in all experimental group have been found. These differences was more expressed when dose of 200 mkg Ge was used. Off spring survival has been high in all groups and was 100% after weaning at 37 days of life. Biological effect of«nanogermanium» citrate in water form was more pronounced in rats, fed 20 or 200 mkg of Germany.