Abstract
Тto investigate the effects of low molecular organic compound (LMOC) on gastric acid secretion (GAS), pepsin output and the activity of Н+,К+-ATPase in the conditions of carbachol stimulation. GAS stimulated by carbachol was measured by method of isolated perfused stomach, pepsin output was analyzed by colorimetric method for 120 minutes and the activity of Н+,К+-ATPase was assessed spectrophotometrically by the level of anorganic phosphate on 20 white laboratory rats. GAS, pepsin output and the Н+,К+-ATPase activity were decreased under the carbachol stimulation after injection of LMOC. LMOC decreases the gastric acid and pepsin secretion in terms of carbachol stimulation. The inhibition of Н+,К+-ATPase activity is considered as mechanism of antisecretory property of LMOC.
Highlights
There are nearly 6 million new registered cases of malignant disease all over the world
Guerin's carcinoma (GC) is a strain of modified cancer derived from the rat spontaneous adenocarcinoma
GC obtained from donor rats was inoculated to the animals by subcutaneous injection (20% suspension of tumor cells in 0.9% NaCI) in rat hindlimb [8]
Summary
There are nearly 6 million new registered cases of malignant disease all over the world. Uterine cancer (adenocarcinoma) is a widespread disease among women ranking 4th place after breast, skin, and gastrointestinal cancers. The rate of uterine cancer incidence increases steadily. In Ukraine, this value is 26.4 per 100,000 population. Women are starting to get sick at the age of 40-54 years old, the peak of the disease occurs at the age of 60-64 years [1,2]. At the present time Guerin's carcinoma (GC) is known to be an optimal model of this pathology for research. GC is a strain of modified cancer derived from the rat spontaneous adenocarcinoma
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