СИНТЕЗ И СВОЙСТВА АДАМАНТИЛСОДЕРЖАЩИХ 1,3-ДИЗАМЕЩЕННЫХ МОЧЕВИН НА ОСНОВЕ ПРОИЗВОДНЫХ ПРОПИОНОВОЙ КИСЛОТЫ - ПОТЕНЦИАЛЬНЫХ МУЛЬТИТАРГЕТНЫХ ИНГИБИТОРОВ SEH И COX-2

Abstract

Known NSAIDs from the group of propionic acid derivatives (naproxen, ketoprofen and flurbiprofen) were converted by reaction with diphenylphosphoryl azide into the corresponding isocyanates with yields of 85-89%. By reacting the resulting isocyanates with (adamantan-1-yl)methylamine, adamantyl-containing ureas were synthesized in yields of 81-90 %. The resulting ureas are potential multi-target inhibitors of soluble epoxide hydrolase (sEH) and cyclooxygenase (COX).