Abstract
A series of conformationally restricted inhibitors of human soluble epoxide hydrolase (sEH) has been developed. Inhibition potency of the described compounds ranges from 4.2 μM to 1.1 nM against recombinant sEH. N-(1-Acetylpiperidin-4-yl)- N′-(adamant-1-yl) urea ( 5a) was found to be a potent inhibitor (IC 50 = 7.0 nM) that was also orally bioavailable in canines.
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