Abstract
The results of pharmaco–toxicological evaluation insectoacaricid preparation «Tsiflur», in particular the study of locally irritating effect of the drug on the skin and mucous membranes of rabbits eyes. The preparation «Tsiflur» – representative of synth pyrethroids, in its composition has the active ingredient cyfluthrin, production NPF «Brovafarma». According to the manufacturer's instructions, the preparation recommended for the control of flying midges and other representatives akaroentomofauny that have veterinary importance. The tool is a clear oily solution of a yellowish color.Experimental studies were conducted on rabbits analogues in several stages. In the first phase we studied local irritant effect of the preparation in varying degrees of dilution when applied to intact skin of rabbits. The aim of the second stage of the research was to determine the local irritant effect of the d preparation on the mucous membrane of the eyes of rabbits.It has been established that the preparation «Tsiflur» in the test concentration (1: 100, 1: 200, 1: 400 concentrate solution) during the observation period did not show locally irritating effects in a single application to the intact areas of the skin of rabbits. Monitoring the bellies of the experiment showed no redness, swelling, thickening of the skin folds and the pain response to palpation place application of the preparation. Not set also signs of toxic effects of native preparation «Tsiflur», when applied under similar conditions. The reaction of the skin of animals per application experimental preparation was valued at 0 points. In the study of the preparation in a similar concentration on the possibility of providing local irritant effect on the mucous membrane of the eyes of rabbits determined that the native application of the preparation led to the emergence of a slight reddening of the eye mucosa and the appearance of watery eyes. These symptoms disappear without any intervention on the second day of the experiment. The reaction to the introduction of the preparation «Tsiflur» was estimated at 1 point, for each identified symptom.
Highlights
Scientific Messenger of Lviv National University of Veterinary Medicine and Biotechnologies named after S.Z
In the first phase we studied local irritant effect of the preparation in varying degrees of dilution when applied to intact skin of rabbits
It has been established that the preparation «Tsiflur» in the test concentration (1: 100, 1: 200, 1: 400 concentrate solution) during the observation period did not show locally irritating effects in a single application to the intact areas of the skin of rabbits
Summary
Scientific Messenger of Lviv National University of Veterinary Medicine and Biotechnologies named after S.Z. Gzhytskyj doi:10.15421/nvlvet7148 У статті наведено результати досліджень місцево–подразнюючої дії нового інсектоакарицидного препарату «Цифлур», на основі синтетичного піретроїду цифлутрину, виробництва НВФ «Бровафарма». Встановлено, що препарат у досліджуваних концентраціях впродовж періоду спостереження не проявив місцево–подразнюючої дії при аплікації на непошкоджений шкірний покрив кролів.
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