Значення наночастинок у транспорті інтерферону

Abstract

The article analyzes the materials of scientific works on the preparation and use of preparations containing interferon and nanoparticles of metals or proteins. The application of a new innovative nanotechnology method using nanoparticles provides broad opportunities for improving the targeted delivery of drugs to the pathological process, implementing an optimal toxicity profile. The purpose of our work was to conduct an analysis of scientific works on the introduction into the medical practice of interferon complexes with nanoparticles of metals or proteins, to identify their advantage and provide a characteristic. It has been established that the nanocomplex obtained can enhance the effectiveness of interferon, reduce its side effects and have controlled release of the drug in the body. Among the antiviral nano-drugs, are actively involved in medical practice - interferon and its derivatives. The system of interferon is on the first line of protection of the organism from infection. Interferon acts on all viruses that enter the body. Taking into account the viral nature of some types of cancer, the interest in using IFN drugs in oncology has increased significantly after their high antiviral activity has been shown. Positive results have been found in the use of IFN in the treatment of chronic hepatitis B and C, condylomatosis and several tumor-like neoplasms, for example, AIDS-related measles, chronic myeloid leukemia, follicular lymphoma, T-cell lymphoma, carcinoma of the tumor, melanoma, and numerous renal cell carcinomas. Employees of the DNU ("State Center for Innovative Biotechnologies") are developing a new preparation of recombinant human interferon with low-dose cerium dioxide. The main purpose relied on this drug - the fight against viral infection and prolonged antitumor action. The named complex successfully runs preclinical and clinical studies. According to the results of experiments in vivo, scientists were able to prolong the action of interferon ox 2 to 5 days. The anti-herpetic activity of cerium dioxide nanoparticles on the model of genital herpes in cavy has been investigated. Numerous experiments indicated the prophylactic and therapeutic efficacy of the use of a complex of cerium dioxide and interferon nanoparticles in a concentration of 1.25 mM In the future, the continuation of work on the creation of a new pharmaceutical drug based on interferon and nanoparticles of the metal to optimize its effectiveness and reduce side effects.