Abstract
The incidence of immune-mediated diseases in children is increasing worldwide. The prevalence of Crohn’s disease reaches 11.4 cases per 100,000 people. The estimated incidence of celiac disease in Russia is 1:100–1:250. The association of Crohn’s disease and celiac disease is quite common. Celiac disease is associated with an 11-fold increase in the risk of inflammatory bowel disease (IBD) compared to control populations; patients with IBD have a 2-fold increased risk for developing celiac disease. This may be due to similarities in pathogenesis. Identical ultrastructural changes in the intestinal mucosa were found in the form of impaired expression of transmembrane proteins (claudin-2, claudin-3, claudin-4, occludin) and cytoplasmic tight junction proteins (zonulin). Celiac disease and Crohn’s disease share many similarities, including in T cell inflammation. Levels of the cytokines IL-17, IL-21, and IFN-γ are elevated in both celiac disease and Crohn’s disease, with high levels of IL-15 being associated only with celiac disease. This article presents a clinical case of Crohn’s disease coexisting with celiac disease in an adolescent. Key words: Crohn’s disease, celiac disease, inflammation, children
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