Взаимосвязь протеинурии, регистрируемой перед родоразрешением, c исходом беременности и родов у пациенток с преэклампсией

Abstract

Study Objective: To assess the association between pre-delivery proteinuria (PU) in patients with preeclampsia and pregnancy/ delivery outcomes for mother and child. Study Design: retrospective study. Materials and Methods. We have conducted a retrospective study of 149 labour and delivery medical records of patients with PU diagnosed before delivery, who had preeclampsia during their pregnancy. Patients were divided into two groups depending on PU severity: moderate and significant PU. We studied the rate of complications for mother and foetus, pregnancy/delivery outcomes for foetus, and anthropometric and demographic parameters of mothers, their somatic conditions, and obstetric history. Study Results. Women with significant PU diagnosed before delivery demonstrated higher statistically and clinically significant risk of HELLP syndrome, as well as increased AAT and ALT activity vs. patients with moderate PU. As for outcomes for newborns, there was a clear statistically significant association between respiratory disorders in child and rate of pre-delivery PU in mother. This complication was recorded more frequently in newborns born to mothers with significant PU vs. moderate PU. Conclusion. An absolute PU quantification before delivery is a method to forecast unfavourable outcomes for mother and child. Keywords: preeclampsia, moderate proteinuria, severe proteinuria, pregnancy and delivery outcomes