Abstract

A series of 6-arylaminopyrimidine-2,4(1H,3H)-diones were synthesized via transamination of 6-aminouracil. Among the target compounds, 3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-yl)aminobenzoic acid methyl ester proved to be an effective endogenous interferon inducer. During biological evaluation followed by a patenting procedure, the ester was assigned the ImmuVag international nonproprietary name.

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