Abstract
Objective of the Review: To analyse clinical and pharmacological characteristics and normative documents in the use of modern proton pump inhibitors (PPI) in paediatric patients in the Russian Federation. Key Points. PPIs remain a widely used and efficient therapy of acid-related disorders in children; however, prescription should be based not only on clinical characteristics of a patient, but also on normative documents, e.g., instructions for the use of PPIs in paediatric population for certain indications approved by the Ministry of Health of Russia, since healthcare providers are responsible for off-label prescriptions. Conclusion. Omeprazole is one of the most well-studied PPIs; it has good evidence base for the use in children; however, in Russia, most omeprazoles have contraindications in paediatric population. Omez is indicated for the management of gastroesophageal reflux and duodenal ulcer caused by Helicobacter pylori in children. Keywords: acid-related disorders, children, paediatrics, proton pump inhibitors, Omeprazole.
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