Клиническая фармакология антибактериальных препаратов в педиатрии

Abstract

Currently, the use of antibacterial drugs is one of the most frequently recommended methods for treating a large number of infectious diseases. However, there are many cases of unjustified antibacterial therapy, errors in the use of antibiotics, irrational combinations, and undesirable drug reactions. And that is why the problem of rational antibiotic therapy remains relevant in modern medicine - the rational use of antibacterial drugs, compliance with strict indications for the use of antibiotics, certain schemes and principles of their use, and the creation of protocols for antibacterial therapy in pediatric practice. The purpose — to present the key issues of clinical pharmacology of antibacterial drugs in Pediatrics. Results. A large number of different microorganisms act as etiological factors of frequent, repeated respiratory diseases. Antibacterial drugs should be prescribed for inflammatory diseases of bacterial etiology and for perioperative prevention. Antibiotics should not be used in the treatment of uncomplicated acute viral respiratory diseases, since they do not have an antiviral effect, do not reduce the temperature, and do not prevent the development of bacterial complications. Conclusion. Thus, today a doctor has a large arsenal of antibacterial drugs and faces a very important task — to use this arsenal rationally. When choosing antibiotics, there are problems associated with the presence of a large number of drugs, the proposed combinations and treatment regimens, polypragmasia, ignorance of modern treatment standards, and a low level of knowledge of clinical pharmacology. In the treatment of life-threatening infections, the cost of the antibiotic should not prevail over the factors of effectiveness and safety.