Abstract
Sarcopenia is a significant health problem in developed countries as it increases the risk of fractures, impairs the ability to move independently and perform daily activities, relates to cardiovascular and respiratory diseases, cognitive impairment, reduces the quality of life, and imposes a financial burden on health care systems. Sarcopenia is characterized by progressive and generalized loss of muscle mass, deterioration in the quality of muscle architecture, and a decrease in muscle functionality, which predicts an unfavorable outcome. Recently, reports have appeared in the literature about the development of sarcopenia in patients with Crohn's disease. However, the mechanism of muscle loss in this inflammatory bowel disease is not fully understood. In this review, we present the possible pathophysiological mechanisms of Crohn's disease that contribute to the development of functional muscle failure and low performance. The literature review also presents potential treatments that may alleviate the development of sarcopenia in Crohn's disease. Key words: sarcopenia, Crohn's disease, inflammatory bowel disease, muscle mass, gut-muscle axis
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