Abstract
Here we report two cases of Epstein-Barr virus related T-cell lymphomas manifested primarily as hemophagocytic syndrome. In case 1, although acute non-A non-B hepatitis with DIC was suspected, bone marrow aspiration was interpreted to be compatible with T cell malignancy. Autopsy revealed a widespread T cell lymphoma with prominent hemophagocytosis by macrophages. The second case was diagnosed as malignant histiocytosis on clinical symptoms and bone marrow findings. Lymph node biopsy was reported as diffuse lage cell lymphoma of T cell origin with reactive macrophages, which was confirmed at autopsy.In both cases, approximately one in each twenty neoplastic cells contained EB virus genomes as revealed by in situ hybridization. HPS in these cases might be explained by reactivation of lymphoma related EB virus. Macrophages should be activated by both viruses and lymphokines which were produced by tumor cells.
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