Системна терапія алергодерматозів у дітей (огляд літератури)

Abstract

Allergic pathology of skin is one of the most pressing problems of modern pediatry. The most common allergic dermatoses: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome). Many aspects of systemic treatment of allergic dermatoses in children are complex and controversial. The modern strategy of treatment of allergic dermatoses in children is based on the principles of evidence-based medicine. According to the international program documents EAACI (European Academy of Allergy and Clinical Immunology), AAAAI (American Academy of Allergy, Asthma & Immunology), PRACТALL (Practical Allergology Consensus Report) treatment of allergic dermatoses consists of: environmental control to eliminate allergenic and non-allergenic factors, skin care, systemic and local pharmacotherapy. Systemic pharmacotherapy includes using drugs of the following groups: antihistamines, glucocorticosteroids, membrane's stabilizators (kromons), leukotriene receptor antagonists, anti-IgE, cytostatics, sorbents, hepatoprotectors, probiotics, vitamins and minerals, antioxidants, sedative medications, enzymes, antibacterial, antifungal and antiviral, immunomodulatory and immunosuppressive medications. Purpose — to increase information on modern possibilities of systemic therapy of allergic dermatoses in children. Conclusions. Systemic pharmacotherapy of allergic dermatoses should be etiopathogenetic and influence the systemic mechanisms of allergic inflammation, which will help control the clinical course of the disease, reduce disability, improve the life quality of patients. No conflict of interest was declared by the authors. Key words: children, allergy, allergic dermatoses, systemic therapy, internal therapy.