Микросферы из оксида иттрия для ядерной медицины

Abstract

Cancers of liver are a problem of modern medicine. A common method of treatment is surgery. In patients who do not need surgery, various methods of local exposure can be prescribed (radiofrequency ablation, chemoembolization, brachytherapy, etc.). In the last decade, a method of treating cancer of liver — radioembolization of the liver-has been introduced into practice. The method is based on selective intra-arterial injection of glass or rubber microspheres containing yttrium radionuclide, resulting in local radiation exposure to tumor tissue. Recently, there has been increasing interest in the production of ceramic microspheres of the yttrium-90 (90Y) isotope. Narrow-fraction microspheres of pure yttrium oxide were obtained as a result of processing yttrium oxide powder in an air RF plasma. The resulting microspheres were subjected to ultrasonic treatment in deionized water, as a result of which the total specific surface area of the particles decreased by 10 %. Yttrium oxide microspheres were etched in a solution of sodium chloride for 11 days, after which the surface of the particles did not undergo significant changes. As a result, microspheres were obtained that have potential applications in nuclear medicine.