Abstract
The article contains modern data about prions and the main prion-associated diseases. The authors describe the main conditions that provide prion-associated infectious diseases, primarily the conformation changes of protein PrPС expressed in healthy tissues of humans and animals and forming the pathogenic PrPSc protein. All prion-caused diseases are considered to be neurodegenerative with fatal outcomes due to a specific spongy brain damage. Information on some aspects of pathogenesis and therapeutic options for prion diseases is presented. The data on the prion safety of biological preparations widely used in healthcare are also presented.
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