Abstract

Peritonitis is a frequent complication in abdominal surgery and is characterized by high mortality. Intestinal insufficiency syndrome is one of the key factors in the progression of peritonitis. The development of motorevacuation dysfunction of the intestine is the most typical and the earliest manifestation of the syndrome of intestinal insufficiency. The cascade of neuro-reflex and humoral reactions of the organism with the development of pronounced microcirculatory disturbances and metabolic changes provide the development of intestinal paresis. The development of internal intestinal and abdominal compression, hypoxic damage of the intestinal mucosa induce the formation of enteric insufficiency at the stage of absorptive-digestive bowel dysfunction. Bacterial translocation starts and induces the progression of multiorgan failure syndrome and determines the severity of endogenous intoxication. The oppression of all the functions of the intestine leads to the so-called «enterargia» – a universal enteral insufficiency.

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