Օդակյաց վերքային վարակի պարագայում հեմոմիկրոցիրկուլյացիայի վիճակի վերաբերյալ / On the state of hemomicrocirculation in the aerobic wound infection

Abstract

The article discusses various aspects of the morphofunctional changes occurring in organs and tissues undergoing aerobic wound processes. In recent years, morphofunctional changes undergoing aerobic wound process have been thoroughly examined, numerous studies have been carried out in order to clarify its morphological, histochemical, immunological, metabolic, and bacteriological aspects, the nature and features of the very wound inflammation process have been refined. Nevertheless, extremely insufficient studies have been carried out into the visceral presentations in aerobic wounds. Quite possibly, it is the structural changes in the internal organs that serve as the basis for the known complications, which in clinical conditions appear as signs of bacteremia, septicemia, and increasing intoxication. In this regard, the study of the state of microcirculation pathways not only in the lesion, but also in different organs and systems is of rather big interest, since the nature of microcirculatory disorders largely determines the characteristics of the course of pathological process at the tissue, organ, and system levels. To sum up the abovementioned, from a morphofunctional point of view, the author of the study has examined the microvasculature of the mesentery under conditions of inducing an aerobic purulent wound process in rats. It has been established that the most severe changes in the system of mesenteric microcirculation pathways occur on the 7th day of the regional pathological process. Changes appear in the form of signs of endothelial cell degeneration, increased vascular permeability, perivascular edema, and lymphocytic infiltration. In the mechanism of increased vascular permeability, tissue basophils play an important role, which is determined by the processes and their intensive degranulation and the histamine delivery into the perivascular space.