Abstract
Evaluation of the hemostatic effect of thrombin formulated in monocomponent dosage forms and combined coatings based on a natural polymer, bacterial cellulose, was an important stage for us in the development of new local hemostatic agents. In vivo and in vitro studies of thrombin preparation in powder and solution forms in various doses (150, 375, 750, and 1500 NIH units), as well as coatings based on bacterial cellulose and thrombin administered into their structure, were conducted. All monocomponent powder formulations of thrombin analyzed were found to have high hemostatic properties. Increasing the dosage of thrombin 2 and 4 times, starting with 375 NIH units, did not lead to a significantly increased hemostatic activity, and the hemostatic effect of the solutions was less than that of powders with a similar level of this enzyme. Thrombin administered to the structure of the coatings does not significantly increase their hemostatic activity; however, it causes a hypercoagulation change according to the findings of in vitro experiments.
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