Abstract
Experiments on hippocampal slices in rats showed that new nicotine acid derivatives LKhT 8-20 and LKhT 9-20 at a concentration of 5 mM inhibited orthrodromic population responses in field СА1 by 89 1 % and 84 2 %, respectively; in comparison, mexicor (reference preparation) in equal concentration inhibited these responses by 52 4 %. Effectiveness of LKhT 8-20 and LKhT 9-20 exceeded that of mexicor in 1.7 and 1.6 times, respectively; LKhT 8-20 exceeded LKhT 9-20 in 1.1 times. Also, in the presence of L-glutamate (0.75 М) LKhT 8-20 (5 mМ) inhibited the evoked neuron responses by 95 2 % and LKhT 9-20 (5 mМ) by 86 1 %. Therefore, LKhT 8-20 and LKhT 9-20 inhibit synaptic transmission between Schaffer collaterals and pyramidal neurons in rat's hippocampal field СА1. Both compounds are L-glutamergic by nature which reveals itself by almost complete in LKhT 8-20 and to a less degree (primarily) in LKhT 9-20. It may be deduced that hippocampus has an important role in the central effect of these new compounds.
Published Version
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